Publications | The Abelson Lab

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Rondeau V, Bansal S, Buttigieg MM, Zeng AGX, Chan DY, Chan-Seng-Yue M, Jin L, McLeod J, Kates M, Donato E, Stelmach P, Vlasschaert C, Yang Y, Gupta A, Genta S, Sanz-Garcia E, Shlush L, Ribeiro M, Butler MO, Abelson S, Minden MD, Saibil SD, Chan SM, Rauh MJ, Trumpp A, Dick JE, Vanner RJ. Response to Immune Checkpoint Blockade is Enhanced in the Presence of Hematopoietic TET2 Inactivation. Cancer Res. 2025 Nov 11. doi: 10.1158/0008-5472.CAN-24-3329. Epub ahead of print. PMID: 41218172.
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Araújo JL, Wagenblast E, Voisin V, McLeod J, Gan OI, Bansal S, Jin L, Mitchell A, Gratton B, Cutting S, Arruda A, Doedens M, Travas A, Kim D, Capo-Chichi JM, Abelson S, Minden MD, Wang JCY, Sobrinho-Simões MA, Pinto-do-Ó P, Lechman E, Dick JE. FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells. Blood. 2025 May 15;145(20):2361-2373. doi: 10.1182/blood.2024025886. PMID: 39841016.
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Scolari FL, Brahmbhatt D, Abelson S, Lee D, Kim RH, Pedarzadeh A, Sakhnini A, Adler A, Chan RH, Dick JE, Rakowski H, Billia F. Clonal haematopoiesis is associated with major adverse cardiovascular events in patients with hypertrophic cardiomyopathy. Eur J Heart Fail. 2024 Oct;26(10):2193-2202. doi: 10.1002/ejhf.3408. Epub 2024 Aug 1. PMID: 39091134.
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Quin C, DeJong EN, McNaughton AJM, Buttigieg MM, Basrai S, Abelson S, Larché MJ, Rauh MJ, Bowdish DME. Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion. Blood Adv. 2024 Aug 13;8(15):4169-4180. doi: 10.1182/bloodadvances.2023011833. PMID: 38924753; PMCID: PMC11334836.
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Perusini MA, Žáčková D, Kim T, Pagnano K, Pavlovsky C, Ježíšková I, Kvetková A, Jurček T, Kim J, Yoo Y, Yi S, Lee H, Kim KH, Chang M, Capo-Chichi JM, Medeiros JJF, Arruda A, Minden M, Zhang Z, Abelson S, Mayer J, Hwan Kim DD. Mutations in myeloid transcription factors and activated signaling genes predict chronic myeloid leukemia outcomes. Blood Adv. 2024 May 28;8(10):2361-2372. doi: 10.1182/bloodadvances.2023012127. PMID: 38447114; PMCID: PMC11127220.
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Nofech-Mozes I, Soave D, Awadalla P, Abelson S. Pan-cancer classification of single cells in the tumour microenvironment. Nat Commun. 2023 Mar 23;14(1):1615. doi: 10.1038/s41467-023-37353-8. PMID: 36959212; PMCID: PMC10036554.
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Lackraj T, Ben Barouch S, Medeiros JJF, Pedersen S, Danesh A, Bakhtiari M, Hong M, Tong K, Joynt J, Arruda A, Minden MD, Kuruvilla J, Bhella S, Kukreti V, Crump M, Prica A, Chen C, Deng Y, Xu W, Pugh TJ, Keating A, Dick JE, Abelson S, Kridel R. Clinical significance of clonal hematopoiesis in the setting of autologous stem cell transplantation for lymphoma. Am J Hematol. 2022 Dec;97(12):1538-1547. doi: 10.1002/ajh.26726. Epub 2022 Sep 26. PMID: 36087071.
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Scolari FL, Brahmbhatt DH, Abelson S, Medeiros JJF, Anker MS, Fung NL, Otsuki M, Calvillo-Argüelles O, Lawler PR, Ross HJ, Luk AC, Anker S, Dick JE, Billia F. Clonal hematopoiesis confers an increased mortality risk in orthotopic heart transplant recipients. Am J Transplant. 2022 Dec;22(12):3078-3086. doi: 10.1111/ajt.17172. Epub 2022 Aug 26. PMID: 35971851.
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Scolari FL, Abelson S, Brahmbhatt DH, Medeiros JJF, Fan CS, Fung NL, Mihajlovic V, Anker MS, Otsuki M, Lawler PR, Ross HJ, Luk AC, Anker S, Dick JE, Billia F. Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock. Eur J Heart Fail. 2022 Sep;24(9):1573-1582. doi: 10.1002/ejhf.2588. Epub 2022 Jul 10. PMID: 35729851.
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Medeiros JJF, Capo-Chichi JM, Shlush LI, Dick JE, Arruda A, Minden MD, Abelson S. SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes-derived data. Bioinformatics. 2022 Apr 12;38(8):2088-2095. doi: 10.1093/bioinformatics/btac081. PMID: 35150236; PMCID: PMC9004652.
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Skead K, Ang Houle A, Abelson S, Agbessi M, Bruat V, Lin B, Soave D, Shlush L, Wright S, Dick J, Morris Q, Awadalla P. Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood. Nat Commun. 2021 Aug 13;12(1):4921. doi: 10.1038/s41467-021-25172-8. PMID: 34389724; PMCID: PMC8363714.
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Wagenblast E, Araújo J, Gan OI, Cutting SK, Murison A, Krivdova G, Azkanaz M, McLeod JL, Smith SA, Gratton BA, Marhon SA, Gabra M, Medeiros JJF, Manteghi S, Chen J, Chan-Seng-Yue M, Garcia-Prat L, Salmena L, De Carvalho DD, Abelson S, Abdelhaleem M, Chong K, Roifman M, Shannon P, Wang JCY, Hitzler JK, Chitayat D, Dick JE, Lechman ER. Mapping the cellular origin and early evolution of leukemia in Down syndrome. Science. 2021 Jul 9;373(6551):eabf6202. doi: 10.1126/science.abf6202. PMID: 34244384.
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Mehdipour P, Marhon SA, Ettayebi I, Chakravarthy A, Hosseini A, Wang Y, de Castro FA, Yau HL, Ishak C, Abelson S, O'Brien CA, De Carvalho DD. Publisher Correction: Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency. Nature. 2021 Mar;591(7850):E20. doi: 10.1038/s41586-021-03329-1. Erratum for: Nature. 2020 Dec;588(7836):169-173. doi: 10.1038/s41586-020-2844-1. PMID: 33654322.
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Abelson S, Zeng AGX, Nofech-Mozes I, Wang TT, Ng SWK, Minden MD, Pugh TJ, Awadalla P, Shlush LI, Murphy T, Chan SM, Dick JE, Bratman SV. Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing. Sci Adv. 2020 Dec 9;6(50):eabe3722. doi: 10.1126/sciadv.abe3722. PMID: 33298453; PMCID: PMC7725472.
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Mehdipour P, Marhon SA, Ettayebi I, Chakravarthy A, Hosseini A, Wang Y, de Castro FA, Loo Yau H, Ishak C, Abelson S, O'Brien CA, De Carvalho DD. Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency. Nature. 2020 Dec;588(7836):169-173. doi: 10.1038/s41586-020-2844-1. Epub 2020 Oct 21. Erratum in: Nature. 2021 Mar;591(7850):E20. doi: 10.1038/s41586-021-03329-1. PMID: 33087935.
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Dobson SM, García-Prat L, Vanner RJ, Wintersinger J, Waanders E, Gu Z, McLeod J, Gan OI, Grandal I, Payne-Turner D, Edmonson MN, Ma X, Fan Y, Voisin V, Chan-Seng-Yue M, Xie SZ, Hosseini M, Abelson S, Gupta P, Rusch M, Shao Y, Olsen SR, Neale G, Chan SM, Bader G, Easton J, Guidos CJ, Danska JS, Zhang J, Minden MD, Morris Q, Mullighan CG, Dick JE. Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs. Cancer Discov. 2020 Apr;10(4):568-587. doi: 10.1158/2159-8290.CD-19-1059. Epub 2020 Feb 21. PMID: 32086311; PMCID: PMC7122013.
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Heidemann S, Bursic B, Zandi S, Li H, Abelson S, Klaassen RJ, Abish S, Rayar M, Breakey VR, Moshiri H, Dhanraj S, de Borja R, Shlien A, Dick JE, Dror Y. Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure. JCI Insight. 2020 Feb 27;5(4):e131018. doi: 10.1172/jci.insight.131018. PMID: 31990679; PMCID: PMC7101147.
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Capo-Chichi JM, Michaels P, Tremblay-Le May R, Abelson S, Hasserjian RP, Xia D. Emerging patterns in clonal haematopoiesis. J Clin Pathol. 2019 Jul;72(7):453-459. doi: 10.1136/jclinpath-2019-205851. Epub 2019 Jun 4. PMID: 31164443.
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Wang TT, Abelson S, Zou J, Li T, Zhao Z, Dick JE, Shlush LI, Pugh TJ, Bratman SV. High efficiency error suppression for accurate detection of low-frequency variants. Nucleic Acids Res. 2019 Sep 5;47(15):e87. doi: 10.1093/nar/gkz474. PMID: 31127310; PMCID: PMC6735726.
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Abelson S, Wang JCY. Age-related clonal hematopoiesis: implications for hematopoietic stem cell transplantation. Curr Opin Hematol. 2018 Nov;25(6):441-445. doi: 10.1097/MOH.0000000000000465. PMID: 30124476.
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Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI. Prediction of acute myeloid leukaemia risk in healthy individuals. Nature. 2018 Jul;559(7714):400-404. doi: 10.1038/s41586-018-0317-6. Epub 2018 Jul 9. PMID: 29988082; PMCID: PMC6485381.
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Sorkin N, Einan-Lifshitz A, Abelson S, Boutin T, Showail M, Borovik A, Ashkenazy Z, Chan CC, Rootman DS. Stepwise Guided Photorefractive Keratectomy in Treatment of Irregular Astigmatism After Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty. Cornea. 2017 Nov;36(11):1308-1315. doi: 10.1097/ICO.0000000000001359. PMID: 28914632.
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Shlush LI, Mitchell A, Heisler L, Abelson S, Ng SWK, Trotman-Grant A, Medeiros JJF, Rao-Bhatia A, Jaciw-Zurakowsky I, Marke R, McLeod JL, Doedens M, Bader G, Voisin V, Xu C, McPherson JD, Hudson TJ, Wang JCY, Minden MD, Dick JE. Tracing the origins of relapse in acute myeloid leukaemia to stem cells. Nature. 2017 Jul 6;547(7661):104-108. doi: 10.1038/nature22993. Epub 2017 Jun 28. PMID: 28658204.
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Rostoker R, Abelson S, Genkin I, Ben-Shmuel S, Sachidanandam R, Scheinman EJ, Bitton-Worms K, Orr ZS, Caspi A, Tzukerman M, LeRoith D. CD24(+) cells fuel rapid tumor growth and display high metastatic capacity. Breast Cancer Res. 2015 Jun 4;17(1):78. doi: 10.1186/s13058-015-0589-9. PMID: 26040280; PMCID: PMC4479226.
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Rostoker R, Abelson S, Bitton-Worms K, Genkin I, Ben-Shmuel S, Dakwar M, Orr ZS, Caspi A, Tzukerman M, LeRoith D. Highly specific role of the insulin receptor in breast cancer progression. Endocr Relat Cancer. 2015 Apr;22(2):145-57. doi: 10.1530/ERC-14-0490. PMID: 25694511; PMCID: PMC4362669.
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Abelson S. Eureka-DMA: an easy-to-operate graphical user interface for fast comprehensive investigation and analysis of DNA microarray data. BMC Bioinformatics. 2014 Feb 24;15:53. doi: 10.1186/1471-2105-15-53. PMID: 24564491; PMCID: PMC3938137.
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Abelson S, Shamai Y, Berger L, Skorecki K, Tzukerman M. Niche-dependent gene expression profile of intratumoral heterogeneous ovarian cancer stem cell populations. PLoS One. 2013 Dec 17;8(12):e83651. doi: 10.1371/journal.pone.0083651. PMID: 24358304; PMCID: PMC3866276.
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Abelson S, Shamai Y, Berger L, Shouval R, Skorecki K, Tzukerman M. Intratumoral heterogeneity in the self-renewal and tumorigenic differentiation of ovarian cancer. Stem Cells. 2012 Mar;30(3):415-24. doi: 10.1002/stem.1029. PMID: 22267284.